Optimized Handling. Uncompromised Performance.


Many commercial DBMs utilize an inert carrier to improve handling, and the proportion of demineralized bone content in the graft varies widely by manufacturer. These carriers do not have a biological function, and they can dilute the osteoinductive potential of the graft.1In addition, carriers can negatively affect the release of growth factors2and functionality of native cells.PliaFX contains 100% bone and provides optimized handling without compromising the osteoconductive and osteoinductive properties necessary for bone formation.
100% Bone: Grows more bone than DBMs containing a carrier, as demonstrated in literature.4
Optimized Handling: Interlocking cortical fibers become moldable upon rehydration and resist migration without the use of a carrier.5
Versatility: Easily mixes with autograft, allograft, and/or fluid of surgeon’s choice.6

1. Han B, Tang B, Nimni ME. Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res. 2003;21(4):648-654.
2. Lee JH, Baek H-R, Lee KM, et al. The Effect of Poloxamer 407-Based Hydrogel on the Osteoinductivity of Demineralized Bone Matrix. Clinics in Orthopedic Surgery. 2014;6(4):455-461.
3. Murphy MB, Suzuki RK, Sand TT, Chaput CD, Gregory CA. Short Term Culture   of Human Mesenchymal Stem Cells with Commercial Osteoconductive Carriers   Provides Unique Insights into Biocompatibility. J Clin Med. 2013;2(3):49-66.
4. Boyan BD, Ranly DM, McMillan J, et al. Osteoinductive Ability of Human Allograft Formulations. J. Periodontol. September 2003.
5. Data on file. LifeNet Health ES-17-090
6. Data on file. LifeNet Health ES-16-085