Wound Management & Surgical Reconstruction (WMSR)

LifeNet Health’s portfolio of allografts offers the most advanced solutions for healing, from soft tissue reconstruction to chronic wounds.

Dermacell AWM® is a human acellular dermal matrix (ADM) that serves as a scaffold to reinforce damaged or inadequate soft tissue at the surgical site. Using LifeNet Health’s proprietary and validated Matracell® decellularization technology, epidermal and dermal cells are removed, while preserving the extracellular matrix (ECM) that aid and are vital in the healing cascade.

Matrion™ is a human placental allograft used as a barrier membrane to treat chronic and acute wounds. Matrion is the first naturally intact placental membrane to incorporate the full trophoblast layer, combined with decellularization using Matracell technology.

ReadiGraft® CryoSkin is cryopreserved human skin composed of frozen fibroblasts and keratinocytes and a fully developed extracellular matrix (ECM) in its epidermal and dermal layers. Cryopreserved human skin provides a biological wound dressing for acute burn injuries.

 

Description
Matrion is one of the first decellularized placental grafts to utilize all three layers of the placental membrane, including the trophoblast layer.
Processed with Matracell® decellularization technology, it is the first naturally intact, full-thickness, decellularized placental membrane. 

 

  • Handling: Matrion’s inclusion of the amnion, chorion and trophoblast layers results in a graft that is up to four times thicker than the Amniotic and Chorionic membranes.1
  • Convenience: No need to rehydrate, thaw or otherwise prepare prior to application.
  • Safety: Up to four times thicker than traditional bilayer grafts, Matrion provides a more substantial barrier, preventing fluid loss as well as bacterial ingress.2
  • Sterility: Sterilized to a Sterility Assurance Level (SAL) of 10-6, medical device grade sterility.3
  • Growth Factor Retention: Matrion retains more endogenous growth factors than other placental membranes that lack the full trophoblast layer.4  Analyses have demonstrated that the trophoblast layer accounts for more than 50% of the total amount of key biological factors in placental tissue.5

Specification Sheet: 


References

1. Matrion Technical Monograph, 68-40-377.00
2. Verbruggen SW, Oyen ML Phillips AT, Nowlan NC. Function and failure of fetal membrane: Modelling the mechanics of the chorion and amnion. PLoS One. 2017; 12(3): e0171588.
3. 10-008, Process, PQ, Method 2B Terminal Sterilization Validation for the Devitalized Dermis Allografts Family
4. Qin, X., Chen, S., Aschenbach, L., Chen, J., inventor; LifeNet Health, assignee. Decellularized placental membrane and methods of preparing and use thereof. WO/2017/112934.
5. LifeNet Health. TR-004-2020 Characterization of the Amnion, Chorion, and Trophoblast Layers of Decellularized and Freeze-Dried Placental Membrane. 2020.
Clinical Application
As a barrier membrane for chronic wounds, including diabetic foot ulcers, venous stasis ulcers, pressure ulcers and dehisced surgical wounds.
Description
Dermacell AWM is a technologically advanced human acellular dermal matrix that is decellularized using Matracell®, a proprietary, patented, and validated processing technology. Matracell removes a minimum of 97% of donor DNA, allowing for rapid cellular infiltration and re-vascularization. Dermacell AWM is terminally sterilized, ready to use without refrigeration or re-hydration.
 
  • Biohospitable: Cells and ≥ 97% donor DNA removed to potentially minimize any adverse patient response
  • Intact Acellular Framework: Retains native growth factors, collagen and elastin
  • Room Temperature Storage: Ready to use out of the package
  • Strength: Pull-out strength and load to failure are comparable to native dermis
  • Sterile: Sterilized to a Sterility Assurance Level (SAL) of 10-6, medical device-grade sterility
  • Structural Support: Facilitates use with sutures, staples
  • Proven: Conducted the largest randomized controlled trial (RCT) to date using hADM in chronic wounds.1

Specification Sheets: 

 

1. Cazzell, S., Vayser, D., Pham H., et al. A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator. Wound Repair and Regeneration. 2017.

Clinical Application

Chronic Wounds* – Diabetic foot ulcers (DFUs), venous stasis ulcers (VSUs), arterial ulcers, pressure ulcers, dehisced surgical wounds, traumatic burns

* Dermacell AWM can be used over exposed tendon, bone, joint capsule, and muscle

Order CodeDescriptionSize
DCELL100

Unmeshed

2 x 2 cm (0.2 - 1 mm thickness)
DCELL101

Unmeshed

4 x 4 cm (0.2 - 1 mm thickness)
DCELL102

Unmeshed

5 x 7 cm (0.2 - 1 mm thickness)
DCELL103

Unmeshed

6 x 7 cm (0.2 - 1 mm thickness)
DCELL104

Unmeshed

4 x 8 cm (0.2 - 1 mm thickness)
DCELL110

Meshed

2 x 2 cm (0.2 - 1 mm thickness)
DCELL111

Meshed

3 x 3 cm (0.2 - 1 mm thickness)
DCELL112

Meshed

4 x 4 cm (0.2 - 1 mm thickness)
DCELL152

Meshed

5 x 7 cm (0.2 - 1 mm thickness)
DCELL153

Meshed

6 x 7 cm (0.2 - 1 mm thickness)
DCELL154

Meshed

4 x 8 cm (0.2 - 1 mm thickness)
DCELL155

Meshed

5 x 9 cm (0.2 - 1 mm thickness)
DCELL156

Meshed

4 x 10 cm (0.2 - 1 mm thickness)
DCELL157

Meshed

6 x 10 cm (0.2 - 1 mm thickness)
DCELL158

Meshed

8 x 10 cm (0.2 - 1 mm thickness)
DCELL159

Meshed

8 x 12 cm (0.2 - 1 mm thickness)
Description

Dermacell is a technologically advanced human acellular dermal matrix that is decellularized using Matracell®, a proprietary, patented and validated processing technology. Matracell removes a minimum of 97% of donor DNA, allowing for rapid cellular infiltration and re-vascularization. Dermacell is terminally sterilized, ready to use without refrigeration or re-hydration.

  • Biohospitable: Cells and ≥ 97% DNA removed to minimize any adverse patient response
  • Intact Acellular Framework: Retains native growth factors, collagen and elastin
  • Room Temperature Storage: Ready to use out of the package via patented Preservon technology
  • Strength: Pull-out strength and load to failure are comparable to existing allograft products
  • Sterile: Sterilized to a Sterility Assurance Level (SAL) of 10-6, medical device-grade sterility

 

Clinical Application
  • Soft Tissue Reconstruction
Room TemperatureDescriptionSize
DCELL200

Unmeshed

4 x 12 cm (0.75 - 1.5 mm thickness)
DCELL201

Unmeshed

6 x 12 cm (0.75 - 1.5 mm thickness)
DCELL202

Unmeshed

4 x 16 cm (0.75 - 1.5 mm thickness)
DCELL203

Unmeshed

5 x 16 cm (0.75 - 1.5 mm thickness)
DCELL204

Unmeshed

6 x 16 cm (0.75 - 1.5 mm thickness)
DCELL205

Unmeshed

8 x 16 cm (0.75 - 1.5 mm thickness)
DCELL206

Unmeshed

8 x 20 cm (0.75 - 1.5 mm thickness)
DCELL207

Unmeshed

16 x 20 cm (0.75 - 1.5 mm thickness)
DCELL208

Unmeshed

20 x 20 cm (0.75 - 1.5 mm thickness)
DCELL209

Unmeshed

20 x 25 cm (0.75 - 1.5 mm thickness)
DCELL250

Unmeshed

4 x 12 cm (1.25 - 2 mm thickness)
DCELL251

Unmeshed

6 x 12 cm (1.25 - 2 mm thickness)
DCELL252

Unmeshed

4 x 16 cm (1.25 - 2 mm thickness)
DCELL253

Unmeshed

5 x 16 cm (1.25 - 2 mm thickness)
DCELL254

Unmeshed

6 x 16 cm (1.25 - 2 mm thickness)
DCELL255

Unmeshed

8 x 16 cm (1.25 - 2 mm thickness)
DCELL256

Unmeshed

8 x 20 cm (1.25 - 2 mm thickness)
DCELL257

Unmeshed

16 x 20 cm (1.25 - 2 mm thickness)
DCELL258

Unmeshed

20 x 20 cm (1.25 - 2 mm thickness)
DCELL259

Unmeshed

20 x 25 cm (1.25 - 2 mm thickness)
DCELL217M

Microperforated

16 x 20 cm (0.6 - 1.05 mm thickness)
DCELL216M

Microperforated

8 x 20 cm (0.6 - 1.05 mm thickness)
DCELL216

Unmeshed

8 x 20 cm (0.6 - 1.05 mm thickness)
DCELL215M

Microperforated

8 x 16 cm (0.6 - 1.05 mm thickness)
DCELL214

Unmeshed

6 x 16 cm (0.6 - 1.05 mm thickness)
DCELL214M

Microperforated

6 x 16 cm (0.6 - 1.05 mm thickness)
DCELL215

Unmeshed

8 x 16 cm (0.6 - 1.05 mm thickness)
Description
Cryopreserved human skin is composed of frozen fibroblasts and keratinocytes, and a fully developed extracellular matrix (ECM) in its epidermis and dermis layers. Cryopreserved human skin provides, upon application, a biological wound dressing for acute burn injuries and other soft tissue needs.
 
  • Biological barrier to minimize the threat of bacterial or fungal contamination
  • Thermoregulation
  • Capacity for regeneration and healing in the recipient
  • Adherence
  • Elasticity
  • Long shelf life
  • Minimal prep time
Clinical Application
  • Biological dressing for traumatic burn injuries
  • 2nd & 3rd degree burns
  • Cosmetic reconstruction after traumatic burn injuries
FrozenDescriptionSize
SK NM

Meshed 

1/8 sq ft or 125 cm² (1.5:1)
SK F

Meshed

1/6 sq ft or 154 cm² (1.5:1)
SK M

Meshed

1/4 sq ft or 232 cm² (1.5:1)
SK Z

Meshed

1/4 sq ft or 232 cm² (2:1)
SK HM

Meshed 

1/2 sq ft or 500 cm² (1.5:1)
SK B

Unmeshed

16 sq cm²
SK N

Unmeshed

1/8 sq ft or 125 cm²
SK S

Unmeshed

1/6 sq ft or 154 cm²
SK P

Unmeshed

1/4 sq ft or 232 cm²
SK H

Unmeshed

1/2 sq ft or 500 cm²
Description

Dermacell AWM Reimbursement Tools

Information regarding Dermacell AWM reimbursement is available in the following guides:

 

For additional information regarding wound reimbursement, please call the Pre-Authorization and Coding Hot-Line at 866-562-6349 or email dermacell@mcra.com.

Description

Matrion Reimbursement Tools

Information regarding Matrion reimbursement is available in the following guides: