PliaFX® Advanced Fiber DBMs

PliaFX® is a family of demineralized bone matrices (DBMs) that contain optimally demineralized fibers1-3† with surface characteristics that set the standard for osseointegration.4-6† 

Available in three configurations to meet a variety of clinical needs: PliaFX Prime (Moldable Demineralized Fibers), PliaFX Pak (Packable Demineralized Fibers with Chips), and PliaFX Flo (Flowable Demineralized Fibers). 


Optimized Handling: Fibers interlock to provide a moldable, intact graft that easily transfers to the surgical site, conforms to the surgical site, and resists migration.1

Versatile: Easily mixes with biomaterials such as autograft or allograft.1,2

Osteoconductive: Large surface area and interconnected network of fibers provide a scaffold that promotes cell attachment and spreading.1†

New Bone Formation Potential: Fibers were readily mineralized as early as 6 weeks when cultured in vivo indicating that the growth factors in the graft can promote bone-forming cells to mineralize the graft given the appropriate microenvironment.1†

Optimally Demineralized: Literature suggests that DBMs with different degrees of residual calcium show significant differences in osteoinductivity.2-4† Every lot of PliaFX DBM undergoes residual calcium testing to ensure lot to lot consistency.1†

Safety: Sterilized using proprietary Allowash XG technology which provides the security of medical device-grade sterility without compromising the biochemical or biomechanical properties of the graft.1-3†

Hydrophilic: The precision-machined fibers are hydrophilic, allowing PliaFX grafts to wick fluid1† and maintain moldable, cohesive handling properties.1-2†

 

  1. Zhang M, Powers RM, and Wolfinbarger L. Effect(s) of the demineralization process on the osteoinductivity of demineralized bone matrix. J Periodontol. 1997; 68:1085-1092
  2. Herold RW, Pashley DH, Cuenin MF, et al. The effects of Varying degrees of Allograft Decalcification on Cultured Porcine Osteoclastcells. J Periodontol. 2002 Feb; 73(2):213-9
  3. Mott DA, Mailhot J, Cuenin MF, et al. Enhancement of osteoblast proliferation in vitro by selective enrichment of demineralized freeze-dried bone allograft with specific growth factors. J Oral Implantol. 2002; 28(2):57-66

  4. J.B. McLean, N. Carter, P. Sohoni, and M. A. Moore, 'Cell Attachment and Osteoinductive Properties of Tissue Engineered, Demineralized Bone Fibers for Bone Void Filling Applications', Clinical Implementation of Bone Regeneration and Maintenance. lntech Open, Feb. 10, 2021. 
     

    †Pre-clinical test data/results may not necessarily be indicative of human clinical performance (or outcomes).