Periodontal Defects

Almost 50%  of adults 30 years and older have some form of periodontal disease and the prevalence increases with age. The global economic burden of periodontal disease remains high. The ultimate goal of periodontal therapy relies on the restoration of all components of the periodontium to their original architecture and function (not just bone stabilization). To achieve this, three factors are required: progenitor cells must migrate to the site (osteoblasts, cementoblasts, and fibroblasts), signals to modulate cellular differentiation and tissue neogenesis (growth factors, for bone and vasculature) and finally a conductive three-dimensional extracellular matrix scaffold to facilitate these processes. The Dental portfolio of LifeNet Health offers specific allograft options to address all these needs for the effective treatment of periodontal defects.

Periodontal Defects

Defect angle as prognostic indicator in the reconstructive therapy of peri‐implantitis. 
Monje, A., Pons, R., Sculean, A., Nart, J., & Wang, H. L. (2023). Clinical implant dentistry and related research.

Treatment of mandibular grade III furcation involvement using platelet-rich fibrin and allogenic graft with 12-month follow-up - A case report. 
Zhou Z, Qi X, Notice T. J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):542-546. doi: 10.1016/j.jobcr.2020.08.012. 

Clinician-centered Outcomes Assessment of Retreatment and Endodontic Microsurgery Using Cone-beam Computed Tomographic Volumetric Analysis.
Curtis DM, VanderWeele RA, Ray JJ, Wealleans JA. J Endod. 2018;44(8):1251-1256. 

Demineralized freeze-dried bone allograft versus platelet-rich fibrin for the treatment of periodontal intrabony defects in humans.
Chadwick JK, Mills MP, Mealey BL. J Periodontol. 2016 Nov; 87(11):1253-1260. 

Combination of bone allograft, barrier membrane and doxycycline in the treatment of infrabony periodontal defects: A comparative trial 
Ashish Agarwal, N.D. Gupta, The Saudi Dental Journal, Volume 27, Issue 3, 2015, Pages 155-160, ISSN 1013-9052,

Efficacy of forced eruption/enamel matrix derivative with freeze-dried bone allograft or with demineralized freeze-dried bone allograft in infrabony defects: A randomized trial.
Ogihara S, Tarnow DP. Quintessence Int. 2015 Jun;46(6):481-490. 

Combination of bone allograft, barrier membrane and doxycycline in the treatment of infrabony periodontal defects: A comparative trial.
Agarwal A, Gupta ND. Saudi Dent J. 2015 Jul; 27(3):155-60. 

Biological Complication in Guided Bone Regeneration With a Polylactic Acid Membrane: A Case Report. 
Mau, Lian Ping DDS*; Cheng, Chih-Wen DDS; Hsieh, Ping-Yen DDS; Jones, Archie A. DDS§. Implant Dentistry 21(3):p 171-174, June 2012. 

Clinical evaluation of demineralized freeze-dried bone allograft and enamel matrix derivative versus enamel matrix derivative alone for the treatment of periodontal osseous defects in humans. 
Gurinsky BS, Mills MP, Mellonig JT. J Periodontol. 2004 Oct; 75(10):1309-1318. 

Small versus large particles of demineralized freeze-dried bone allografts in human intrabony periodontal defects.
Fucini SE, Quintero G, Gher ME, Black BS, Richardson AC. J Periodontol. 1993 Sept; 64(9):844-847. 

Evaluation of a collagen membrane with and without bone grafts in treating periodontal intrabony defects.
Chen CC, Wang HL, Smith F, Glickman GN, Shyr Y, O’Neal RB. J Periodontol. 1995 Oct; 66(10):838-847. 

Comparison of bioabsorbable laminar bone membrane and non-resorbable ePTFE membrane in mandibular furcations. 
Scott TA, Towle HJ, Assad DA, Nicoll BK.J Periodontol. 1997;68(7):679-686.


Guided bone regeneration for dehiscence and fenestration defects on implants using an absorbable polymer barrier.
Rosen PS, Reynolds MA. J Periodontol. 2001 Feb; 72(2):250-6.

Guided bone regeneration around titanium implants: report of the treatment of 1,503 sites with clinical reentries.
Fugazzotto PA, Shanaman R, Manos T, Shectman R. Int J Periodontics Restorative Dent. 1997 Jun; 17(3):292, 293-9.