Matrion®

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Instructions for Use
Product Specifications

Matrion

Matrion is one of the first decellularized placental grafts to utilize all three layers of the placental membrane, including the trophoblast layer.
Processed with Matracell® decellularization technology, it is the first naturally intact, full-thickness, decellularized placental membrane.
  • Handling: Matrion’s inclusion of the amnion, chorion and trophoblast layers results in a graft that is up to four times thicker than the Amniotic and Chorionic membranes.1
  • Convenience: No need to rehydrate, thaw or otherwise prepare prior to application.
  • Safety: Up to four times thicker than traditional bilayer grafts, Matrion provides a more substantial barrier, preventing fluid loss as well as bacterial ingress.2
  • Sterility: Sterilized to a Sterility Assurance Level (SAL) of 10-6, medical device grade sterility.3
  • Growth Factor Retention: Matrion retains more endogenous growth factors than other placental membranes that lack the full trophoblast layer.4  Analyses have demonstrated that the trophoblast layer accounts for more than 50% of the total amount of key biological factors in placental tissue.5
Clinical Application
As a barrier membrane for chronic wounds, including diabetic foot ulcers, venous stasis ulcers, pressure ulcers and dehisced surgical wounds.
References
  1. Matrion Technical Monograph, 68-40-377.00
  2. Verbruggen SW, Oyen ML Phillips AT, Nowlan NC. Function and failure of fetal membrane: Modelling the mechanics of the chorion and amnion. PLoS One. 2017; 12(3): e0171588.
  3. 10-008, Process, PQ, Method 2B Terminal Sterilization Validation for the Devitalized Dermis Allografts Family
  4. Qin, X., Chen, S., Aschenbach, L., Chen, J., inventor; LifeNet Health, assignee. Decellularized placental membrane and methods of preparing and use thereof. WO/2017/112934.
  5. LifeNet Health. TR-004-2020 Characterization of the Amnion, Chorion, and Trophoblast Layers of Decellularized and Freeze-Dried Placental Membrane. 2020.